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Intrathecal Immune Response in Patients with the Post-Polio Syndrome NEJM 325:749-755, Sharief,M.K.,et al, 1991 See this aricle in Pubmed Article Abstract Oligoclonal IgM bands specific to poliovirus were detected in the cerebrospinal fluid of 21 of the 36 patients with the post-polio syndrome (58 percent)but in none of the control group(p<0.0001).In quantitative studies there was evidence of increased intrathecal synthesis of IgM antibodies to poliovirus only among the patients with the post-polio syndrome;there was no increased synthesis of IgM to measles,mumps,herpes simplex,or varicella-zoster viruses.The patients with post-polio syndrome had significantly higher mean(+/-SD)cerebrospinal fluid levels of interleukin-2 and soluble interleukin-2 receptors than the controls(8.1+/- 5.3 vs 1.4+/-0.8 U per milliter and 159.6+/-102.9 vs 10.7+/-6.2 U per milliter,respectively).The intrathecal synthesis of IgM antibodies to poliovirus correlated with the cerebrospinal fluid concentrations of interleukin-2(p<0.0005)and soluble interleukin-2 receptors(P<0.001).An intrathecal immune response against poliovirus is present in many patients with the post-polio syndrome.In some of these patients the recrudescence of muscle weakness may be caused by persistent or recurrent infection of neural cells with the poliovirus.

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(click to filter results - removes previous filter) cerebrospinal fluid cerebrospinal fluid,abnormal cerebrospinal fluid,oligoclonal IgM in poliomyelitis post polio syndrome

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